Krupp Center for Integrative Research

Center Base Path
research

Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet

This pilot study investigated how a short-term anti-inflammatory dietary intervention might reduce pain and inflammation in individuals with rheumatoid arthritis (RA). Over a two-week period, participants followed a specialized diet (ITIS) rich in omega-3 fats, antioxidants, and anti-inflammatory ingredients like turmeric, while avoiding pro-inflammatory foods such as red meat, gluten, nightshades, and lactose. Researchers observed improvements in joint tenderness, swelling, and overall disease activity, suggesting dietary changes may complement standard RA treatments.

Study findings and publications may be found under the Outcomes section of this website.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Clinical, Inflammatory, and Microbiome Effects of Dietary Modification in Women With Endometriosis

This study aimed to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet can improve gut microbiome diversity, quality of life, pain, and inflammation in women with endometriosis. Study outcomes were measured before and after a 3-month intervention, including dietary counseling, online cooking classes, and individual and group health coach sessions. Study findings and publications can be found under the Outcomes section of this website.

Principal Investigator(s)

Sanjay Agarwal, MD 

Rob Knight, PhD
Lauren Foster, PhD
Gordon Saxe, MD, PhD 

Primary Center

Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Antipsychotics in Early Psychosis

This 6-week double-blinded trial examines whether individuals in the early stages of psychosis (EP) respond to 1000 mg of endocannabinoids (CBD) with the aim of improving positive, negative, and cognitive symptoms of psychosis. Researchers are exploring the possibility that CBD might reduce anxiety, and perhaps normalize biological stress response. Symptoms, eating behaviors, metabolic parameters, cannabinoid, and biomarkers of inflammation and cortisol are measured at baseline, 3 weeks and end of study in a population with a diagnosis of first episode psychosis who are stabilized on antipsychotic medication.

Principal Investigator(s)

Kristin Cadenhead, MD

Heline Mirzakhanian, Ph.D
Cris Achim, MD, Ph.D  

Email
krupp-wellness@health.ucsd.edu
Primary Center

Aromatherapy and Healing Visual Art for Hospitalized Cancer Patients

The study aimed to evaluate the feasibility and explore the potential effects of using aromatherapy and visual mindfulness as complementary therapies to address pain and nausea in hospitalized cancer patients. Aromatherapy involves olfactory stimulation of selected scents via a patch, and visual mindfulness involves watching curated videos by cinematographer Louie Schwartzberg.

Principal Investigator(s)

Jay Varughese, MD

Alice Chen, DO

Primary Center

Mushrooms as COVID-19 Vaccine Adjunct

A randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety of FoTv (a combination of two polypore mushrooms, Fomitopsis officinalis, and Trametes versicolor) in an adult population at the time of COVID-19 vaccination. Researchers examined the effect of FoTv vs. placebo for use as an adjunct to vaccination for COVID-19. Vaccine-related side effects following COVID-19 vaccination were examined in both study groups.  

Study-related publication(s) may be found in the Outcomes section of this website. 

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Randomized Controlled Trial (RCT) of Immune Supporting Mushrooms for COVID-19

A multi-centered, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety of FoTv (a combination of two polypore mushrooms, Fomitopsis officinalis and Trametes versicolor) for COVID-positive outpatients with mild-to-moderate symptoms. Researchers used changes in COVID-19 viral load, blood markers, and a 14-day symptom diary to examine the safety, feasibility, and preliminary effects of the study product versus placebo. Study findings and publications may be found under the Outcomes section of this website.


 

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Mitigating Toxic Impact: The Role of Melatonin, Coenzyme Q10, and N-Acetylcysteine in Post-Exposure Protection

This study is in development, and recruitment has not yet begun. Once approved, additional information about study goals, eligibility, and participation requirements will be shared here. In the meantime, you may contact the study team using the email address on this page for more information.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Plant-Based Dietary Intervention for Chronic Lymphocytic Leukemia (CLL) Patients

This study aimed to determine the feasibility of a whole food, plant-based (WFPB) dietary intervention in low-risk patients with chronic lymphocytic leukemia (CLL). Secondary outcomes explored whether adherence to a WFPB diet was associated with changes in CLL biomarkers and anthropometric measures of cardiometabolic health. The intervention included 8 live cooking classes, and multiple individual sessions with both a dietitian and health coach.  

Principal Investigator(s)

Ariel Portera, DO

Michael Choi, MD
Melanie Fiorella, MD 

Email
krupp-wellness@health.ucsd.edu
Primary Center

Chinese Herbs for COVID-19 Treatment Randomized Trial

A multi-centered, randomized, double-blinded, placebo-controlled clinical trial evaluated the safety of mQFPD as a modified form of Qing Fei Pai Du Tang (a Chinese herbal formula that has widely been used in Asia for COVID-positive outpatients with mild-to-moderate symptoms). Researchers used COVID-19 viral load, blood markers, and a 14-day symptom diary to examine the safety, feasibility, and preliminary effects of the study product versus placebo. Study findings and latest publications may be found under the Outcomes section of this website.

Principal Investigator(s)

Andrew Shubov, MD

Gordon Saxe, MD, PhD
Lan Kao, DACM, LAc

Email
krupp-wellness@health.ucsd.edu
Primary Center

Randomized Controlled Trial (RCT) of a Nutritional Intervention for Endometriosis

This study aims to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet is effective at improving quality of life and pain, and decreasing inflammation in women with endometriosis. Study outcomes will be measured before and after a 3-month intervention, which includes dietary counseling, education materials, recorded cooking classes, and health coaching sessions.

Study Activities

The purpose of this randomized controlled study is to investigate the effectiveness of a 3-month dietary intervention on the quality of life, pain, and inflammation in women with endometriosis. The intervention includes learning and adapting to the Whole Food Plant-Based diet. The diet consists of key plant foods and eliminates animal-based products and processed foods. The study activities also include three visits to complete questionnaires aimed at addressing the study's clinical objectives and to provide blood samples for inflammatory biomarker analysis.

Participant Benefits

Dietary orientation and expert nutrition counseling; WFPB diet education materials and resources; food basket, recipes, and manuals to learn and practice healthy eating.

Eligibility Criteria

Women between 18-45 years old with a diagnosis of Endometriosis who are in stable health condition and medications for the past 3 months

Additional Information

Additional study eligibility and participation requirements may be reviewed with the study coordinator. Don't hesitate to get in touch with us for screening.

Principal Investigator(s)
Study Duration
12 weeks/3 months
Email
krupp-wellness@health.ucsd.edu
Primary Center