The Effect of Anti-Inflammatory Diet on Clinical and Biologic Outcomes in Long-COVID (PASC) Patients

This study aims to assess the feasibility of a 12-week anti-inflammatory diet (ITIS) among Long-COVID (PASC) patients. This study also explores diet-induced changes in clinical symptoms and plasma inflammatory marker levels. The intervention includes individualized dietary counseling plus 2 weeks of ITIS. 

Study analysis in progress.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Glutathione Support for Health: A Randomized Trial

This randomized, placebo-controlled study aimed to determine the feasibility and potential effects on glutathione status using a Whole-Food Plant-Based (WFPB) diet among an adult population with type-2 diabetes. The intervention group included educational classes and meal-planning recommendations aiming to increase the intake of glutathione-rich foods.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet

This pilot study investigated how a short-term anti-inflammatory diet might reduce pain and inflammation in individuals with rheumatoid arthritis (RA). Over a two-week period, participants followed a diet rich in omega-3 fats, antioxidants, and anti-inflammatory ingredients like turmeric, while avoiding pro-inflammatory foods such as red meat, gluten, and lactose. Researchers observed improvements in joint tenderness, swelling, and overall disease activity, suggesting dietary changes may complement standard RA treatments.

Read the published abstract on the 2019 ACR/ARP Annual Meeting site.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Clinical, Inflammatory, and Microbiome Effects of Dietary Modification in Women With Endometriosis

This study aimed to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet can improve gut microbiome diversity, quality of life, pain, and inflammation in women with endometriosis. Study outcomes were measured before and after a 3-month intervention, including dietary counseling, online cooking classes, and individual and group health coach sessions.

Principal Investigator(s)

Sanjay Agarwal, MD 

Rob Knight, PhD
Lauren Foster, PhD
Gordon Saxe, MD, PhD 

Email
krupp-wellness@health.ucsd.edu

Plant-Based Dietary Intervention for Chronic Lymphocytic Leukemia (CLL) Patients

This study aims to determine the feasibility of a whole food, plant-based (WFPB) dietary intervention in low-risk patients with Chronic Lymphocytic Leukemia (CLL). Secondary outcomes explored whether adherence to a WFPB diet was associated with changes in CLL biomarkers and biomarkers and anthropometric measures of cardiometabolic health. The intervention included 8 live cooking classes, and multiple individual sessions with both a dietitian and health coach.

Principal Investigator(s)

Ariel Portera, DO

Michael Choi, MD
Melanie Fiorella, MD 

Email
krupp-wellness@health.ucsd.edu

RCT of a Nutritional Intervention for Endometriosis

This study aims to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet is effective at improving quality of life and pain, and decreasing inflammation in women with endometriosis. Study outcomes will be measured before and after a 3-month intervention, which includes dietary counseling, education materials, recorded cooking classes, and health coaching sessions.

Study Activities

The purpose of this randomized controlled study is to investigate the effectiveness of a 3-month dietary intervention on the quality of life, pain, and inflammation in women with endometriosis. The intervention includes learning and adapting to the Whole Food Plant-Based diet. The study activities also include three visits to complete questionnaires aimed at addressing the study's clinical objectives and to provide blood samples for inflammatory biomarker analysis.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Osteopathic Manipulative Treatment in Newborns with Breastfeeding Difficulties

This randomized, placebo-controlled study aims to determine improvements in breastfeeding difficulty of hospitalized newborns. The control group receives doctor-distributed standard educational handouts regarding breastfeeding. The intervention group receives a 30-minute Osteopathic manipulative treatment (OMT) session, provided daily until discharge. 

This study is in development, and recruitment has not yet begun. Once approved, additional information about study goals, eligibility, and participation requirements will be shared here. In the meantime, you may contact the study team using the email address on this page for more information.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Time-Restricted and Healthy Eating in Hepatocellular Carcinoma

A feasibility and safety study of a time-restricted, healthy eating intervention in patients undergoing liver-directed therapies for Hepatocellular carcinoma (HCC). This twelve-month intervention will focus on prolonged nightly fasting combined with a Whole-Food Plant-Based (WFPB) diet. Successful completion of this feasibility study will provide preliminary data for a larger, appropriately powered, trial to examine effects on HCC clinical outcome.

Study Activities
  • Participants will receive nutritional counseling and health coaching on nightly fasting and healthy eating habits throughout the 12-month study.
  • They will wear a continuous glucose monitor and an accelerometer for a total of two weeks, follow a whole food, plant-based eating plan, attend four clinic visits in La Jolla, and complete assessments and questionnaires. Participants will also track their eating times daily in the Guava health tracker app.
Participant Benefits

While direct health benefits cannot be guaranteed, prolonged nightly fasting could improve sleep, stabilize blood sugar, reduce inflammation, and enhance metabolic health. Eligible participants who complete all study visits and requirements may receive up to $200 in compensation.

Eligibility Criteria

Participants must be 18 years or older, have a BMI greater than 27 kg/m², currently practice nightly fasting of less than 12 hours, and be diagnosed with early or mid-stage liver cancer referred for liver-directed therapy.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)

Nicholas Webster, PhD

Isabel Newton, MD 

Study Duration
12 months
Study Compensation
Up to $200
Email
krupp-wellness@health.ucsd.edu
Phone Number
619-929-0828