RCT of a Nutritional Intervention for Endometriosis

This study aims to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet is effective at improving quality of life and pain, and decreasing inflammation in women with endometriosis. Study outcomes will be measured before and after a 3-month intervention, which includes dietary counseling, education materials, recorded cooking classes, and health coaching sessions.

Study Activities

The purpose of this randomized controlled study is to investigate the effectiveness of a 3-month dietary intervention on the quality of life, pain, and inflammation in women with endometriosis. The intervention includes learning and adapting to the Whole Food Plant-Based diet. The study activities also include three visits to complete questionnaires aimed at addressing the study's clinical objectives and to provide blood samples for inflammatory biomarker analysis.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Time-Restricted and Healthy Eating in Hepatocellular Carcinoma

A feasibility and safety study of a time-restricted, healthy eating intervention in patients undergoing liver-directed therapies for Hepatocellular carcinoma (HCC). This twelve-month intervention will focus on prolonged nightly fasting combined with a Whole-Food Plant-Based (WFPB) diet. Successful completion of this feasibility study will provide preliminary data for a larger, appropriately powered, trial to examine effects on HCC clinical outcome.

Study Activities
  • Participants will receive nutritional counseling and health coaching on nightly fasting and healthy eating habits throughout the 12-month study.
  • They will wear a continuous glucose monitor and an accelerometer for a total of two weeks, follow a whole food, plant-based eating plan, attend four clinic visits in La Jolla, and complete assessments and questionnaires. Participants will also track their eating times daily in the Guava health tracker app.
Participant Benefits

While direct health benefits cannot be guaranteed, prolonged nightly fasting could improve sleep, stabilize blood sugar, reduce inflammation, and enhance metabolic health. Eligible participants who complete all study visits and requirements may receive up to $200 in compensation.

Eligibility Criteria

Participants must be 18 years or older, have a BMI greater than 27 kg/m², currently practice nightly fasting of less than 12 hours, and be diagnosed with early or mid-stage liver cancer referred for liver-directed therapy.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)

Nicholas Webster, PhD

Isabel Newton, MD 

Study Duration
12 months
Study Compensation
Up to $200
Email
krupp-wellness@health.ucsd.edu
Phone Number
619-929-0828

Preoperative Flavanols Supplementation in Elderly Patients to Reduce Inflammatory Markers and Improve Mitochondrial Function

Led by Dr. Byron Fergerson, Clinical Professor and Vice Chair of Anesthesiology at UCSD Health, this study evaluates a flavanol-based supplement aimed at supporting recovery and overall health in patients 50 years or older preparing for hip or knee replacement surgery.

Study Activities

Participants will complete two in-home blood draws, take one 500 mg capsule daily for 14 days, log their intake, and answer questionnaires.

Participant Benefits

While direct health benefits cannot be guaranteed, the flavanol supplement may reduce inflammation and support antioxidant activity. Other possible benefits include improved cognition, mood, and recovery. Participants may receive up to $100 upon completion.

Eligibility Criteria
  • Age 50 or older
  • Reside in San Diego County
  • Scheduled for hip or knee replacement surgery
Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)
Study Duration
2 weeks
Study Compensation
Up to $100
Email
krupp-wellness@health.ucsd.edu
Phone Number
619‑929‑0828

Weight Management: Dissemination and Implementation of Shared Medical Appointments at UC San Diego Health

The UCSD Supervised Lifestyle and Integrative Medicine (SLIM) Program for the treatment of obesity is a virtual SMA program that has a curriculum based on USPSTF recommendations for intensive lifestyle change and meets the requirements of ITLC outlined in the American College of Lifestyle Medicine position statement on ITLC.

It is run by the UC San Diego Center for Integrative Medicine, and in-person assessment visits take place at the UC San Diego Center for Weight Management. The program consists of 12 visits, covering all six pillars of Lifestyle Medicine. There are 2 pre-intervention visits for initial assessments and tailored recommendations and 2 follow-up assessments.

Study Activities

Participation includes 12 virtual group appointments, 2 pre-intervention visits, and 2 post-intervention assessments, focused on lifestyle education and personalized weight management support.

Participant Benefits

Education and tools for long-term weight management through evidence-based lifestyle interventions and support from an integrative health team.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Study Duration
6 months
Email
krupp-wellness@health.ucsd.edu
Phone Number
858‑413‑7728

Ophthalmology and Diet – Shiley Eye Institute

Glaucoma affects about 80 million people worldwide and is the leading cause of blindness. While there’s no cure, emerging evidence suggests dietary changes—specifically using “food as medicine”—may influence intraocular pressure and systemic health. Shiley Eye Institute and the KCIR are conducting a study examining eye health under a whole‑foods, plant‑based (WFPB) diet.

Study Activities
  • Learning healthy cooking basics and trying therapeutic recipes
  • Developing understanding of the energetics of food, cooking, and eating
  • Attending cooking classes and group meetings (support persons encouraged)
  • Blood samples for DNA, diet, and visual function analysis
  • Various eye tests to assess current eye health
Participant Benefits

Education and practical skills in healthy cooking, dietary support, and comprehensive eye health assessments.

Eligibility Criteria

Men or women ages 18–80 with stable open‑angle glaucoma. Additional eligibility requirements may be reviewed with the study coordinator.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Study Duration
12 months (6 months observation, 6 months active)
Study Compensation
Up to $225
Email
krupp-wellness@health.ucsd.edu
Phone Number
858‑822‑1643

Rheumatoid Arthritis and Anti-Inflammatory Diet – with the Division of Rheumatology

Dr. Monica Guma from the Division of Rheumatology at UC San Diego, together with the Center for Integrative Nutrition and Research, is conducting a study of a 3-month long program to test nutritional changes for patients with rheumatoid arthritis.

Study Activities

There will be four, one-hour, face-to-face visits required. Participation will also involve education and support in the adoption of a healthy and nutritionally balanced anti-inflammatory diet. The program includes a detailed baseline orientation, expert nutrition counseling and education, and telephone coaching.

Participant Benefits

Education and support in adopting a healthy and nutritionally balanced anti-inflammatory diet.

Eligibility Criteria

Any patient with rheumatoid arthritis without food allergies can participate.

Additional Information

If you are interested in the study and would like further details, please contact the Nutrition Rheumatoid Arthritis Study Coordinator. You may also review the study flyer here.

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)
Study Duration
3 months
Email
z2manalo@health.ucsd.edu
Phone Number
858-822-3745

Evaluating the Effects of Magnesium on Arterial Compliance and Cerebral Blood Flow

This feasibility study aims to examine whether 12 weeks of magnesium supplementation (450 mg magnesium citrate 3x day with food) might increase cerebral blood flow and reduce the stiffness of the medium-sized arteries in the brain of obese patients with metabolic syndrome. Blood and MRI are measured before and after the intervention.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)

Thomas Liu, PhD

Ryan Bradley, ND, MPH

Study Duration
12 weeks
Email
krupp-wellness@health.ucsd.edu
Phone Number
858-249-6896

Integrative Prehabilitation Program for Patients Facing Surgery

This study supports patients undergoing gastrointestinal cancer surgery with a comprehensive integrative care plan. The program includes services before and after surgery and is led by UC San Diego experts in mindfulness, dietetics, and exercise physiology.

Study Activities

Participants engage in a 3–5 month program that includes:

  • Mindfulness sessions
  • Dietary counseling
  • Exercise consultations
Participant Benefits

All services are provided at no cost. Participants may experience improved surgical outcomes, reduced anxiety, and enhanced overall well-being.

Eligibility Criteria
  • Adults ages 18–75 undergoing major abdominal surgery for gastrointestinal cancer
  • Must enroll at least 4 weeks—and no more than 3 months—prior to surgery
Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)

Jula Veerapong, MD

Jenn Lee, MD

Study Duration
5 weeka
Email
krupp-wellness@health.ucsd.edu
Phone Number
858-413-7728

Integrative Plant-Based Diet & Behavioral Interventions for Patients with Laryngopharyngeal Reflux

This study explores an 8‑week integrative nutrition and speech therapy program inclusive of a standard of care visits including one in-person speech therapy assessment and six telehealth visits with registered dietitians and SLPs.

Study Activities

The intervention includes a Principal Investigator–led orientation video; counseling with dietitians and speech language therapists; two telehealth nutrition assessments; food journals and speech assessments.

Participant Benefits

Access to dietitian and SLP counseling, comprehensive assessments, and telehealth support for lifestyle and dietary changes.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)
Study Duration
8 weeks
Email
krupp-wellness@health.ucsd.edu
Phone Number
858‑249‑6896

Anti-Inflammatory Rich Diet in First Episode Psychosis

The goal of the study is multi-faceted: develop and test a diet intervention based on anti-inflammatory, wholesome foods using continuous feedback from early psychosis patients and their families; evaluate the feasibility, satisfaction, and adherence of a 5-week diet intervention in 12 patients with early psychosis and explore whether a 5-week adherence to an anti-inflammatory wholesome foods diet effects weight, metabolic parameters, biomarkers, symptoms of psychosis, and overall well-being.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Principal Investigator(s)

Helen Mirzakhanian, PhD

Kristin Cadenhead, MD, Gordon Saxe MD, PhD 

Email
krupp-wellness@health.ucsd.edu
Phone Number
619-543-7816