The Effect of Anti-Inflammatory Diet on Clinical and Biologic Outcomes in Long-COVID (PASC) Patients

This study aims to assess the feasibility of a 12-week anti-inflammatory diet (ITIS) among Long-COVID (PASC) patients. This study also explores diet-induced changes in clinical symptoms and plasma inflammatory marker levels. The intervention includes individualized dietary counseling and 2 weeks of a Long-COVID ITIS diet plan including a food basket of key ingredients, recipes, and manuals to learn how to follow an anti-inflammatory diet.

Study analysis in progress.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Glutathione Support for Health: A Randomized Trial

This randomized, placebo-controlled study aimed to determine the feasibility and potential effects on glutathione status using a Whole-Food Plant-Based (WFPB) diet among an adult population with type-2 diabetes. The intervention group included educational classes and meal-planning recommendations aiming to increase the intake of glutathione-rich foods.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet

This pilot study investigated how a short-term anti-inflammatory dietary intervention might reduce pain and inflammation in individuals with rheumatoid arthritis (RA). Over a two-week period, participants followed a specialized diet (ITIS) rich in omega-3 fats, antioxidants, and anti-inflammatory ingredients like turmeric, while avoiding pro-inflammatory foods such as red meat, gluten, nightshades, and lactose. Researchers observed improvements in joint tenderness, swelling, and overall disease activity, suggesting dietary changes may complement standard RA treatments.

Study findings and publications may be found under the Outcomes section of this website.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Clinical, Inflammatory, and Microbiome Effects of Dietary Modification in Women With Endometriosis

This study aimed to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet can improve gut microbiome diversity, quality of life, pain, and inflammation in women with endometriosis. Study outcomes were measured before and after a 3-month intervention, including dietary counseling, online cooking classes, and individual and group health coach sessions.

Principal Investigator(s)

Sanjay Agarwal, MD 

Rob Knight, PhD
Lauren Foster, PhD
Gordon Saxe, MD, PhD 

Email
krupp-wellness@health.ucsd.edu
Primary Center

Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Antipsychotics in Early Psychosis

This 6-week double-blinded trial examines whether individuals in the early stages of psychosis (EP) respond to 1000 mg of endocannabinoids (CBD) with the aim of improving positive, negative, and cognitive symptoms of psychosis. Researchers are exploring the possibility that CBD might reduce anxiety, and perhaps normalize biological stress response. Symptoms, eating behaviors, metabolic parameters, cannabinoid, and biomarkers of inflammation and cortisol are measured at baseline, 3 weeks and end of study in a population with a diagnosis of first episode psychosis who are stabilized on antipsychotic medication.

Principal Investigator(s)

Kristin Cadenhead, MD

Heline Mirzakhanian, Ph.D
Cris Achim, MD, Ph.D  

Email
krupp-wellness@health.ucsd.edu
Primary Center

Aromatherapy and Healing Visual Art for Hospitalized Cancer Patients

The study aimed to evaluate the feasibility and explore the potential effects of using aromatherapy and visual mindfulness as complementary therapies to address pain and nausea in hospitalized cancer patients. Aromatherapy involves olfactory stimulation of selected scents via a patch, and visual mindfulness involves watching curated videos by cinematographer Louie Schwartzberg.

Study findings and publications may be found under the Outcomes section of this website.

Principal Investigator(s)

Jay Varughese, MD

Alice Chen, DO

Email
krupp-wellness@health.ucsd.edu
Primary Center

Randomized Controlled Trial (RCT) of Immune Supporting Mushrooms for COVID-19

A multi-centered, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety of FoTv (a combination of two polypore mushrooms, Fomitopsis officinalis and Trametes versicolor) for COVID-positive outpatients with mild-to-moderate symptoms. Researchers used changes in COVID-19 viral load, blood markers, and a 14-day symptom diary to examine the safety, feasibility, and preliminary effects of the study product versus placebo. Study findings and publications may be found under the Outcomes section of this website.


 

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Mitigating Toxic Impact: The Role of Melatonin, Coenzyme Q10, and N-Acetylcysteine in Post-Exposure Protection

This study is in development, and recruitment has not yet begun. Once approved, additional information about study goals, eligibility, and participation requirements will be shared here. In the meantime, you may contact the study team using the email address on this page for more information.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Osteopathic Manipulative Treatment in Newborns with Breastfeeding Difficulties

This randomized, placebo-controlled study aims to determine improvements in breastfeeding difficulty of hospitalized newborns. The control group receives doctor-distributed standard educational handouts regarding breastfeeding. The intervention group receives a 30-minute Osteopathic manipulative treatment (OMT) session, provided daily until discharge. 

This study is in development, and recruitment has not yet begun. Once approved, additional information about study goals, eligibility, and participation requirements will be shared here. In the meantime, you may contact the study team using the email address on this page for more information.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Weight Management: Dissemination and Implementation of Shared Medical Appointments at UC San Diego Health

The UCSD Supervised Lifestyle and Integrative Medicine (SLIM) Program for the treatment of obesity is a virtual SMA program that has a curriculum based on USPSTF recommendations for intensive lifestyle change and meets the requirements of ITLC outlined in the American College of Lifestyle Medicine position statement on ITLC.

It is run by the UC San Diego Center for Integrative Medicine, and in-person assessment visits take place at the UC San Diego Center for Weight Management. The program consists of 12 visits, covering all six pillars of Lifestyle Medicine. There are 2 pre-intervention visits for initial assessments and tailored recommendations and 2 follow-up assessments.

Study Activities

Participation includes 12 virtual group appointments, 2 pre-intervention visits, and 2 post-intervention assessments, focused on lifestyle education and personalized weight management support.

Participant Benefits

Education and tools for long-term weight management through evidence-based lifestyle interventions and support from an integrative health team.

Additional Information

Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.

Study Duration
6 months
Email
krupp-wellness@health.ucsd.edu
Phone Number
858‑413‑7728
Primary Center