Nutritional Intervention for College Students with Depression

This pilot feasibility study examines whether an 8-week nutritional intervention is acceptable and practical for college students experiencing symptoms of depression. The study investigates how sleep, meal timing, and diet interact to influence mood and daily rhythms in a population vulnerable to circadian disruption. Findings will inform the design of larger clinical trials evaluating lifestyle-based interventions for depression.

Study Activities

Participants take part in a 10–12-week study that includes a 2-week baseline assessment followed by an 8-week dietary intervention. Participants are randomly assigned to follow either a Mediterranean diet alone or a Mediterranean diet combined with time-restricted eating. The Mediterranean diet emphasizes fruits, vegetables, whole grains, legumes, nuts, and healthy fats such as olive oil, while limiting red meat and highly processed foods. Study activities include completing questionnaires, wearing a sleep and activity monitoring device, and logging meals using a mobile app. The study includes four visits, two of which involve individualized dietary counseling delivered via telehealth, along with ongoing educational materials and optional additional support throughout the intervention period.

Participant Benefits

While direct benefits cannot be guaranteed, some participants may experience improvements in mood, sleep, or overall well-being. Participants will receive personalized dietary guidance from a registered dietitian and may receive up to $150 in compensation for completing study requirements.

Eligibility Criteria

Eligible participants are college students aged 18 years or older who are experiencing symptoms of depression.

Principal Investigator(s)

Michael McCarthy, MD, PhD

 

Study Duration
10-12 weeks
Study Compensation
$150
Email
timedstudy@ucsd.edu
Phone Number
(858) 247-1409
Primary Center

Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Antipsychotics in Early Psychosis

This 6-week double-blinded trial examines whether individuals in the early stages of psychosis (EP) respond to 1000 mg of endocannabinoids (CBD) with the aim of improving positive, negative, and cognitive symptoms of psychosis. Researchers are exploring the possibility that CBD might reduce anxiety, and perhaps normalize biological stress response. Symptoms, eating behaviors, metabolic parameters, cannabinoid, and biomarkers of inflammation and cortisol are measured at baseline, 3 weeks and end of study in a population with a diagnosis of first episode psychosis who are stabilized on antipsychotic medication.

Principal Investigator(s)

Kristin Cadenhead, MD

Heline Mirzakhanian, Ph.D
Cris Achim, MD, Ph.D  

Email
krupp-wellness@health.ucsd.edu
Primary Center

Aromatherapy and Healing Visual Art for Hospitalized Cancer Patient

The study aims to evaluate the feasibility and explore the potential effects of using aromatherapy and visual mindfulness as complementary therapies in patients undergoing inpatient treatment for pain and nausea. Aromatherapy involves olfactory stimulation of selected scents via a patch, and visual mindfulness involves watching curated videos by cinematographer Louie Schwartzberg.

Study analysis in progress.

Principal Investigator(s)

Jay Varughese, MD

Alice Chen, DO

Email
krupp-wellness@health.ucsd.edu
Primary Center

Mitigating Toxic Impact: The Role of Melatonin, Coenzyme Q10, and N-Acetylcysteine in Post-Exposure Protection

This study is in development, and recruitment has not yet begun. Once approved, additional information about study goals, eligibility, and participation requirements will be shared here. In the meantime, you may contact the study team using the email address on this page for more information.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center

Plant-Based Dietary Intervention for Chronic Lymphocytic Leukemia (CLL) Patients

This study aims to determine the feasibility of a whole food, plant-based (WFPB) dietary intervention in low-risk patients with Chronic Lymphocytic Leukemia (CLL). Secondary outcomes explored whether adherence to a WFPB diet was associated with changes in CLL biomarkers and biomarkers and anthropometric measures of cardiometabolic health. The intervention included 8 live cooking classes, and multiple individual sessions with both a dietitian and health coach.

Principal Investigator(s)

Ariel Portera, DO

Michael Choi, MD
Melanie Fiorella, MD 

Email
krupp-wellness@health.ucsd.edu
Primary Center

Chinese Herbs for COVID-19 Treatment Randomized Trial

A multi-centered, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety of mQFPD as a modified form of Qing Fei Pai Du Tang (a Chinese herbal formula that has widely been used in Asia for COVID-positive outpatients with mild-to-moderate symptoms). Researchers used COVID-19 viral load, blood markers, and a 14-day symptom diary to examine the safety, feasibility, and preliminary effects of the study product versus placebo.

Principal Investigator(s)

Andrew Shubov, MD

Gordon Saxe, MD, PhD
Lan Kao, DACM, LAc

Email
krupp-wellness@health.ucsd.edu
Primary Center

RCT of a Nutritional Intervention for Endometriosis

This study aims to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet is effective at improving quality of life and pain, and decreasing inflammation in women with endometriosis. Study outcomes will be measured before and after a 3-month intervention, which includes dietary counseling, education materials, recorded cooking classes, and health coaching sessions.

Study Activities

The purpose of this randomized controlled study is to investigate the effectiveness of a 3-month dietary intervention on the quality of life, pain, and inflammation in women with endometriosis. The intervention includes learning and adapting to the Whole Food Plant-Based diet. The diet consists of key plant foods and eliminates animal-based products and processed foods. The study activities also include three visits to complete questionnaires aimed at addressing the study's clinical objectives and to provide blood samples for inflammatory biomarker analysis.

Participant Benefits

Dietary orientation and expert nutrition counseling; WFPB diet education materials and resources; food basket, recipes, and manuals to learn and practice healthy eating.

Eligibility Criteria

Women between 18-45 years old with a diagnosis of Endometriosis who are in stable health condition and medications for the past 3 months

Additional Information

Additional study eligibility and participation requirements may be reviewed with the study coordinator. Don't hesitate to get in touch with us for screening.

Principal Investigator(s)
Study Duration
12 weeks/3 months
Email
krupp-wellness@health.ucsd.edu
Primary Center

Osteopathic Manipulative Treatment in Newborns with Breastfeeding Difficulties

This randomized, placebo-controlled study aims to determine improvements in breastfeeding difficulty of hospitalized newborns. The control group receives doctor-distributed standard educational handouts regarding breastfeeding. The intervention group receives a 30-minute Osteopathic manipulative treatment (OMT) session, provided daily until discharge. 

This study is in development, and recruitment has not yet begun. Once approved, additional information about study goals, eligibility, and participation requirements will be shared here. In the meantime, you may contact the study team using the email address on this page for more information.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu
Primary Center