The Effect of Anti-Inflammatory Diet on Clinical and Biologic Outcomes in Long-COVID (PASC) Patients

This study aims to assess the feasibility of a 12-week anti-inflammatory diet (ITIS) among Long-COVID (PASC) patients. This study also explores diet-induced changes in clinical symptoms and plasma inflammatory marker levels. The intervention includes individualized dietary counseling plus 2 weeks of ITIS. 

Study analysis in progress.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Glutathione Support for Health: A Randomized Trial

This randomized, placebo-controlled study aimed to determine the feasibility and potential effects on glutathione status using a Whole-Food Plant-Based (WFPB) diet among an adult population with type-2 diabetes. The intervention group included educational classes and meal-planning recommendations aiming to increase the intake of glutathione-rich foods.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet

This pilot study investigated how a short-term anti-inflammatory diet might reduce pain and inflammation in individuals with rheumatoid arthritis (RA). Over a two-week period, participants followed a diet rich in omega-3 fats, antioxidants, and anti-inflammatory ingredients like turmeric, while avoiding pro-inflammatory foods such as red meat, gluten, and lactose. Researchers observed improvements in joint tenderness, swelling, and overall disease activity, suggesting dietary changes may complement standard RA treatments.

Read the published abstract on the 2019 ACR/ARP Annual Meeting site.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Dietary Interventions to Improve Vision

This study aimed to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet can improve visual function in open-angle glaucoma (OAG) patients. Study outcomes were measured before and after a 6-month intervention including dietary counseling, online cooking classes, health coaching, and support group sessions.

Principal Investigator(s)

Linda Zangwill, PhD 

Robert N. Weinreb, MD
Gordon Saxe, MD, PhD 

Email
krupp-wellness@health.ucsd.edu

Clinical, Inflammatory, and Microbiome Effects of Dietary Modification in Women With Endometriosis

This study aimed to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet can improve gut microbiome diversity, quality of life, pain, and inflammation in women with endometriosis. Study outcomes were measured before and after a 3-month intervention, including dietary counseling, online cooking classes, and individual and group health coach sessions.

Principal Investigator(s)

Sanjay Agarwal, MD 

Rob Knight, PhD
Lauren Foster, PhD
Gordon Saxe, MD, PhD 

Email
krupp-wellness@health.ucsd.edu

Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Antipsychotics in Early Psychosis

This 6-week double-blinded trial examines whether individuals in the early stages of psychosis (EP) respond to 1000 mg of endocannabinoids (CBD) with the aim of improving positive, negative, and cognitive symptoms of psychosis. Researchers are exploring the possibility that CBD might reduce anxiety, and perhaps normalize biological stress response. Symptoms, eating behaviors, metabolic parameters, cannabinoid, and biomarkers of inflammation and cortisol are measured at baseline, 3 weeks and end of study in a population with a diagnosis of first episode psychosis who are stabilized on antipsychotic medication.

Principal Investigator(s)

Kristin Cadenhead, MD

Heline Mirzakhanian, Ph.D
Cris Achim, MD, Ph.D  

Email
krupp-wellness@health.ucsd.edu

Aromatherapy and Healing Visual Art for Hospitalized Cancer Patient

The study aims to evaluate the feasibility and explore the potential effects of using aromatherapy and visual mindfulness as complementary therapies in patients undergoing inpatient treatment for pain and nausea. Aromatherapy involves olfactory stimulation of selected scents via a patch, and visual mindfulness involves watching curated videos by cinematographer Louie Schwartzberg.

Study analysis in progress.

Principal Investigator(s)

Jay Varughese, MD

Alice Chen, DO

Email
krupp-wellness@health.ucsd.edu

Mushrooms as COVID-19 Vaccine Adjuvant

A randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety of FoTv (a combination of two polypore mushrooms, Fomitopsis officinalis, and Trametes versicolor) in an adult population at the time of COVID-19 vaccination. Researchers examined the effect of FoTv vs. placebo for use as an adjunct to vaccination for COVID-19. Vaccine-related side effects following COVID-19 vaccination were examined in both study groups.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

RCT of Immune Supporting Mushrooms for COVID-19

A multi-centered, randomized, double-blinded, placebo-controlled clinical trial to evaluate the safety of FoTv (a combination of two polypore mushrooms, Fomitopsis officinalis and Trametes versicolor) for COVID-positive outpatients with mild-to-moderate symptoms. Researchers used changes in COVID-19 viral load, blood markers, and a 14-day symptom diary to examine the safety, feasibility, and preliminary effects of the study product versus placebo. 


 

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Plant-Based Dietary Intervention for Chronic Lymphocytic Leukemia (CLL) Patients

This study aims to determine the feasibility of a whole food, plant-based (WFPB) dietary intervention in low-risk patients with Chronic Lymphocytic Leukemia (CLL). Secondary outcomes explored whether adherence to a WFPB diet was associated with changes in CLL biomarkers and biomarkers and anthropometric measures of cardiometabolic health. The intervention included 8 live cooking classes, and multiple individual sessions with both a dietitian and health coach.

Principal Investigator(s)

Ariel Portera, DO

Michael Choi, MD
Melanie Fiorella, MD 

Email
krupp-wellness@health.ucsd.edu