Krupp Center for Integrative Research

A Whole Food Plant-based Diet for Endometriosis (122)

A Whole Food Plant-based Diet for Endometriosis (122)

Welcome to our study and thank you for your participation!

Dr. Sanjay Agarwal and his team are studying how diet may affect pain and inflammation in women with endometriosis. The goal of this study is to find out if changing what you eat can help reduce the painful symptoms of endometriosis.


Study Personnel Contacts

Kathleen – Dietitian
kabundy@health.ucsd.edu

Phoebe – Health Coach
psenowitz@health.ucsd.edu

Chloe – Study Coordinator
c1delgadoramirez@health.ucsd.edu 

Introduction

Nutrition can influence inflammation, hormone balance, and the bacteria in your gut. These factors can affect symptoms of endometriosis and may be improved by certain dietary strategies. In this study, we are examining if a whole-food, plant-based diet can reduce the pain of endometriosis and improve quality of life by reducing inflammation in the body.

As a study participant, you will receive complimentary personalized dietary counseling at three points during the intervention. Each session will last about 30–45 minutes.

You will take part in a series of four weekly cooking demonstration videos, where you’ll explore new foods, learn how to prepare balanced plant-based meals, and build your cooking skills. Each cooking class will take about 1.5 hours.

To help you get started, you’ve received a pantry bag with key ingredients for the classes. You’ll need to have some basic pantry staples on hand and purchase fresh produce each week.

Throughout the study, you will also receive educational materials to support learning about nutrition and plant-based diets.

During the study, we will call you on two different days at three timepoints to complete a 24-hour food recall with one of our staff. At the beginning of the study (week 1), mid-point (week 6), and at the end of the study (week 12). At each timepoint, we will call you on 2 different days to obtain a detailed report of your food and beverage intake over the previous 24hrs.Please use the following portion size reference to help in providing details of portion sizes you are eating

As part of this study, we recommend consuming key plant-based food groups and avoiding animal-based products and processed foods. The following instructions will help you complete the diet. Please read the documents carefully, watch the videos in their entirety, and contact the research team if you have any questions.

Cooking Demonstration Series 

In the cooking demonstration series orientation during your second nutrition visit, we will review the cooking manual and menus, pantry bag ingredients, resources, equipment needs, what to expect, and how to set yourself up for success with whole foods plant-based cooking at home. Please reference pages 14-16 in your manual for organizing tips and 6 easy recipes to get started. 

There will be one video class weekly over 4 weeks. You can choose any day or time during the week for cooking. You may consider dedicating a consistent weekly time for grocery shopping and cooking.


Each Friday, you will receive an email with the following:

  • The weeks menu and recipes
  • Ingredients needed: pantry bag, pantry, and fresh
  • Equipment needed
  • What to prep ahead

For the 4 week period, please complete each weekly activity in the manual.

Cooking Class Manual

Please review the 2 videos on kitchen equipment and cutting techniques before the start of class.

To become familiar with a variety of cooking techniques, follow the links for short instructional videos in the Appendix–Basic Cooking Techniques, pages 56- 59.

Cooking Class One

In class one we will be focusing on food and diet quality for balanced meals. Please reference pages 5-16 for educational information with weekly activity and pages 72-74 for class recipes in your cooking class manual.

Class One Menu

Miso Soup, Steamed Greens, French Lentils, Quinoa & Radish Salad, Roasted Seed & Herb Dressing, Fruit Compote 

Pantry Bag items to use: 

  • Wakame flakes-1 tsp + 1 Tbsp
  • Sesame seeds- ½ c
  • Umeboshi vinegar- 3 Tbsp
  • Toasted sesame oil- 2 Tbsp
  • Petit French lentils- 1 cup
  • brown rice vinegar- 4 Tbsp
  • Miso paste- 1 tsp 

Please prepare the following before the start of class:

  • Wash vegetables

Cooking Class Two 

In class two we are focusing on phytonutrients which are compounds found in plant foods that help our bodies become healthy. Please reference pages 17-27 for educational information and pages 75-77 for class recipes in your cooking class manual.

Class Two Menu

Sweet Vegetable Drink, Colorful Massaged Kale Salad, White Bean Hummus, Cauliflower Millet Mash, Shitake Mushroom Gravy, Cucumber Citrus Seaweed Salad 

Pantry Bag items to use: 

  • Kombu-1” piece
  • Wakame- 1 Tbsp
  • Dried shitake- 4-5
  • Sesame seeds- 2 Tbsp
  • Millet- 1 cup
  • Dried white beans- 1 cup
  • Tahini- 3 Tbsp
  • Kudzu starch- 1 Tbsp
  • Tamari- 2 Tbsp
  • Miso- 2 Tbsp 

Please prepare the following before the start of class:

  • Soak white beans
  • Wash vegetables

Cooking Class Three 

In class three we are focusing on functional foods. Functional foods are foods that have been studied and used for their health-promoting, disease-preventing properties. Please reference pages 28-38 for educational information and pages 78-80 for class recipes in your cooking class manual.

Class Three Menu

Kukicha Tea, Sautéed Greens & Garlic, Adzuki Beans & Squash, Brown Basmati Stir Fry, Roasted Roots with Sea Vegetables, Fruit Water Sauté. 

Pantry Bag items to use: 

  • Dulse-1 Tbsp
  • Sesame oil- 2 Tbsp
  • Adzuki beans- 1 cup
  • Kukicha tea- 1 Tbsp
  • Tamari -2 Tbsp
  • Brown rice vinegar- 1 Tbsp
  • Kudzu starch- 1 Tbsp 

Please prepare the following before the start of class:

Night Before

  • Soak adzuki beans

Day of

  • Wash vegetables

Cooking Class Four 

In class three we are focusing on meal planning and how to sustain a whole foods, plant-based diet in the future. Please reference pages 39-54 for educational information and pages 81-83 for class recipes in your cooking class manual.

Class Four Menu

Colorful Cabbage Coleslaw, Buckwheat Patties, Marinated Tempeh & Gravy, Veggie Au Gratin, Fruit Smoothie 

Pantry Bag items to use: 

  • Pumpkin seeds-1 cup
  • Buckwheat- 2 cups
  • Umeboshi plum paste-1 Tbsp
  • Kudzu starch-1 Tbsp
  • Brown rice vinegar- ½ cup
  • Tamari-2 Tbsp

Please prepare the following before the start of class:

Night Before

  • Marinate tempeh according to recipe
  • Soak ¼ cup raw nuts of your choice for Fruit Smoothie

Day of

  • Separately, rinse almonds and pumpkin seeds and allow to dry in strainers  
  • Wash vegetables

Krupp Endowed Fund RFA

Request for Applications for Fiscal Year 2026–27 Funding

Summary

The UC San Diego Krupp Center for Integrative Research (KCIR) Krupp Endowed Fund (KEF) is soliciting applications for funding beginning July 1, 2026. These awards are funded up to $50,000 per year for 1–2 years, up to $100,000 total. Applicants must be responsive to the Primary Aim, Primary Objective, and Research Priorities as described below.

The Effect of Anti-Inflammatory Diet on Clinical and Biologic Outcomes in Long-COVID (PASC) Patients

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Study analysis in progress.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

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Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

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Read the published abstract on the 2019 ACR/ARP Annual Meeting site.

Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu

Clinical, Inflammatory, and Microbiome Effects of Dietary Modification in Women With Endometriosis

This study aimed to determine whether increasing consumption of a Whole-Food Plant-Based (WFPB) diet can improve gut microbiome diversity, quality of life, pain, and inflammation in women with endometriosis. Study outcomes were measured before and after a 3-month intervention, including dietary counseling, online cooking classes, and individual and group health coach sessions.

Principal Investigator(s)

Sanjay Agarwal, MD 

Rob Knight, PhD
Lauren Foster, PhD
Gordon Saxe, MD, PhD 

Email
krupp-wellness@health.ucsd.edu

Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Antipsychotics in Early Psychosis

This 6-week double-blinded trial examines whether individuals in the early stages of psychosis (EP) respond to 1000 mg of endocannabinoids (CBD) with the aim of improving positive, negative, and cognitive symptoms of psychosis. Researchers are exploring the possibility that CBD might reduce anxiety, and perhaps normalize biological stress response. Symptoms, eating behaviors, metabolic parameters, cannabinoid, and biomarkers of inflammation and cortisol are measured at baseline, 3 weeks and end of study in a population with a diagnosis of first episode psychosis who are stabilized on antipsychotic medication.

Principal Investigator(s)

Kristin Cadenhead, MD

Heline Mirzakhanian, Ph.D
Cris Achim, MD, Ph.D  

Email
krupp-wellness@health.ucsd.edu

Aromatherapy and Healing Visual Art for Hospitalized Cancer Patient

The study aims to evaluate the feasibility and explore the potential effects of using aromatherapy and visual mindfulness as complementary therapies in patients undergoing inpatient treatment for pain and nausea. Aromatherapy involves olfactory stimulation of selected scents via a patch, and visual mindfulness involves watching curated videos by cinematographer Louie Schwartzberg.

Study analysis in progress.

Principal Investigator(s)

Jay Varughese, MD

Alice Chen, DO

Email
krupp-wellness@health.ucsd.edu

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Principal Investigator(s)
Email
krupp-wellness@health.ucsd.edu