The UC San Diego Krupp Center for Integrative Research is committed to contributing to the growing body of scientific research in the field of integrative medicine and health. We sponsor innovative integrative medicine approaches that show the greatest promise of bettering human health for the largest number of people at the lowest cost.

Our Practice-Based Research Network and Center of Excellence for Research and Training in Integrative Health (CoERTIH) support outcomes tracking and collaboration across UC San Diego and the region. The Krupp Endowed Fund offers annual research grants reviewed each spring and awarded at the start of the university’s fiscal year. Applicants must be UC San Diego employees and KEF members; non-members may serve as co-investigators.

Preoperative Flavanols Supplementation in Elderly Patients to Reduce Inflammatory Markers and Improve Mitochondrial Function

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A 2-week study testing a daily flavanol supplement in patients over 50 preparing for joint replacement. Includes blood draws, daily intake logs, and assessments of anti-inflammatory, cognitive, and recovery-related outcomes.

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Preoperative Flavanols Supplementation in Elderly Patients to Reduce Inflammatory Markers and Improve Mitochondrial Function

Weight Management: Dissemination and Implementation of Shared Medical Appointments at UC San Diego Health

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A 6-month virtual shared medical appointment (SMA) program for weight management based on intensive lifestyle change. Includes in-person assessments and covers all six pillars of Lifestyle Medicine through 12 group visits and personalized support.

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Weight Management: Dissemination and Implementation of Shared Medical Appointments at UC San Diego Health

Ophthalmology and Diet – Shiley Eye Institute

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This 12-month study evaluates how a whole-foods, plant-based diet may affect open-angle glaucoma. Participants join cooking classes, group sessions, and receive eye exams and bloodwork to explore connections between food, metabolic health, and visual function.

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Ophthalmology and Diet – Shiley Eye Institute

Rheumatoid Arthritis and Anti-Inflammatory Diet – with the Division of Rheumatology

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A 3-month study testing how nutritional changes impact rheumatoid arthritis. Participants attend four in-person visits and receive expert counseling, education, and coaching to adopt a healthy, anti-inflammatory diet supported by the Division of Rheumatology and Integrative Nutrition.

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Rheumatoid Arthritis and Anti-Inflammatory Diet – with the Division of Rheumatology

Evaluating the Effects of Magnesium on Arterial Compliance and Cerebral Blood Flow

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This feasibility study aims to examine whether 12 weeks of magnesium supplementation (450 mg magnesium citrate 3x day with food) might increase cerebral blood flow and reduce the stiffness of the medium-sized arteries in the brain of obese patients with metabolic syndrome.

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Evaluating the Effects of Magnesium on Arterial Compliance and Cerebral Blood Flow

Integrative Plant-Based Diet & Behavioral Interventions for Patients with Laryngopharyngeal Reflux

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An 8-week program for patients with laryngopharyngeal reflux that combines telehealth nutrition counseling, speech therapy, food journaling, and assessments. The study includes a speech evaluation, telehealth visits, and a PI-led orientation video.

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Integrative Plant-Based Diet & Behavioral Interventions for Patients with Laryngopharyngeal Reflux

Mitigating Toxic Impact: The Role of Melatonin, Coenzyme Q10, and N-Acetylcysteine in Post-Exposure Protection

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This study is currently in the planning phase. Details about objectives, eligibility, and participation will be available once recruitment begins.

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Mitigating Toxic Impact: The Role of Melatonin, Coenzyme Q10, and N-Acetylcysteine in Post-Exposure Protection

Osteopathic Manipulative Treatment in Newborns with Breastfeeding Difficulties

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This randomized, placebo-controlled study aims to determine improvements in breastfeeding difficulty of hospitalized newborns. This study is in development, and recruitment has not yet begun.

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Osteopathic Manipulative Treatment in Newborns with Breastfeeding Difficulties