A feasibility and safety study of a time-restricted, healthy eating intervention in patients undergoing liver-directed therapies for Hepatocellular carcinoma (HCC). This twelve-month intervention will focus on prolonged nightly fasting combined with a Whole-Food Plant-Based (WFPB) diet. Successful completion of this feasibility study will provide preliminary data for a larger, appropriately powered, trial to examine effects on HCC clinical outcome.
- Participants will receive nutritional counseling and health coaching on nightly fasting and healthy eating habits throughout the 12-month study.
- They will wear a continuous glucose monitor and an accelerometer for a total of two weeks, follow a whole food, plant-based eating plan, attend four clinic visits in La Jolla, and complete assessments and questionnaires. Participants will also track their eating times daily in the Guava health tracker app.
While direct health benefits cannot be guaranteed, prolonged nightly fasting could improve sleep, stabilize blood sugar, reduce inflammation, and enhance metabolic health. Eligible participants who complete all study visits and requirements may receive up to $200 in compensation.
Participants must be 18 years or older, have a BMI greater than 27 kg/m², currently practice nightly fasting of less than 12 hours, and be diagnosed with early or mid-stage liver cancer referred for liver-directed therapy.
Additional eligibility requirements may be reviewed with the study coordinator, please contact us for screening.