Krupp Center for Integrative Research
PBR Resources
The National Institutes of Health (NIH) is emphasizing the importance of Practice-Based Research (PBR) as a practical and real-world approach to advancing clinical research. Few physicians have training in the importance of and how to implement PBR. We host periodic one-day CME workshops to inform clinical faculty how to conduct PBR within their clinics to advance this important clinical research initiative.
The Value of PBR
- Sets new standards for integrative health through validated methods
- Advances integrative medicine in preventing and treating chronic disease
- Highlights the role of natural therapies in both acute and chronic care
- Expands awareness and access to integrative care across healthcare
PBR Course Learning Objectives
- Enhance motivation and ability of clinical faculty to direct and conduct funded Practice-Based Research
- Identify resources, structures, and processes needed to support faculty in conducting PBR
- Create actionable ideas for multiple PBR projects that engage clinical teams
Practice-Based Research (PBR) and Pragmatic Studies Workshop Materials
PBR Worksheet
Fill out this worksheet to help us understand your PBR needs.
Practical issues in implementing PBR
Wilson Pace, MD, University of Colorado, Denver
Discusses the advances of Integrative Medicine research and how it is influencing the direction of allopathic practice.
Integrative Medicine PBR; BRAVENET and PRIMIER
Jeffery A. Dusek, PhD, Integrative Health Research Center, Penny George Institute for Health and Healing
Discusses the advances of Integrative Medicine research and how it is influencing the direction of allopathic practice.
Overview of PBR Efforts at UC San Diego
Rusty Kallenberg, MD, & William Sieber, PhD, UC San Diego
Learn about opportunities at UC San Diego, and how to move your practice forward with PBR.
Resources and Pilot Grants to Support PBR
Paul J. Mills, PhD, UC San Diego
Discover resources and funding to support your PBR ideas.
Research designs appropriate for PBR
Shahrokh Golshan, PhD, UC San Diego
Presents and discusses different design and statistical issues involved in common and practical PBR trial designs and how to collaborate with a statistician.
Qualitative Assessments
Samantha Hurst, PhD, UC San Diego
Informs attendees about the use of qualitative data in developing contextualized evaluation/research efforts in their practices, including bridging qualitative data with quantitative data in mixed methods designs.
Identifying proper and practical endpoints; The Promise of PROMIS
Rusty Kallenberg, MD, UC San Diego
Discusses the NIH PROMIS questionnaire system and how to use it for PBR.
Core Services
Researchers in integrative health face distinct challenges in designing, managing, and translating their work into meaningful outcomes. In order to aid researchers, and in order to reduce the cost and improve efficiency of our grants, the Krupp Center for Integrative Health accelerates this process by offering expert guidance, operational support, and specialized tools across every stage of research through a coordinated suite of core services. To learn more or inquire about support for your project, contact us.
Study Design & Regulatory Support
We help researchers build a strong foundation for their work through research design and statistical consultation, support with IRB application development and other regulatory correspondence, and guidance on selecting appropriate questionnaires and assessments. Our team ensures your study is methodologically sound and ethically aligned from the start.
Research design and statistical consultation
Project/study management
Regulatory correspondence support
Grant application development
IRB application development
Questionnaire / assessments selection
Grant & Project Development
From idea to implementation, we offer expert assistance with grant application development, comprehensive project and study management, and manuscript preparation to support successful funding, execution, and dissemination. Whether you're launching a new study or preparing results for publication, we’re here to help every step of the way.
Database development
Data collection and management
Manuscript preparation
Clinical research coordination support
Clinical & Integrative Support
Enhancing both participant care and study design, our services include consultation in complementary and integrative medicine, dietary counseling, and wellness coaching. These offerings provide added depth to research protocols while supporting overall health outcomes.
CAM/IM modalities consultation
Health and Wellness coaching
Dietary counseling and intervention
PI Portal
Coming soon...
Apply for a Grant
KCIR members are eligible to apply for a Krupp Award; if this is your first time applying for an award, ensure you have completed a membership application. Before diving into the award application process, please review the Request for Applications (RFA) document below. In order to plan for your online submission, we offer the invitation to review potential project ideas that may be developed. We will advise applicants on potential relevance of concept ideas as they relate to the objectives of the Krupp Endowed Fund (KEF). Submitting a concept idea for review is not necessary. After an idea is well-developed, application for an award begins with a Letter of Intent (LOI).
Step 1
Review the RFA
Read this essential in-depth document will provide all the necessary information about applying for a Krupp Award, from eligibility and expected timelines to format specifications of submissions.
Step 2
KCIR Membership
Membership is required for applicants seeking funding from the Krupp Endowment Fund. Submit a membership application first, then proceed to the next step.
Step 3
Concept Idea Form
Ensure the concept idea is relevant to the aim and objective of the Krupp Center for Integrative Research by submitting a concept idea for review. Our team will provide early feedback, which is key to ensuring efficiency and developing a stronger application.
Step 4
Submit LOI
Submit a Letter of Intent (LOI). Outline the research question, target population, methods, and how your work advances integrative health. LOIs are evaluated based on eligibility, scientific merit, cost efficiency.
Step 5
Grant Application
Upon review and approval of the Concept Idea and LOI, a grant application will be sent directly to the Principal Investigator for completion.
Step 6
Fund Awarded
If grant application is approved, KCIR staff will coordinate with the awardee(s) to ensure funding is distributed to the research project.
Comparing the ITIS Diet and the Mediterranean Diet in Rheumatoid Arthritis: Preliminary Findings on Clinical and Microbiome Outcomes

Clinical and Biological Changes in Rheumatoid Arthritis Patients Exposed to an Anti-inflammatory Diet

Groundbreaking FDA-Approved Study: Mushrooms and Chinese Herbs for COVID-19

Trials Test Mushrooms and Herbs as Anti–COVID-19 Agents

Mushrooms and herbs tested to combat COVID-19
